The Role of Cytokines in Inflammatory Process of Knee Osteoarthritis: Systematic Review

Osteoarthritis (OA) is a degenerative joint disorder that occurs in cartilage. OA the main cause of disability adults and generally characterized by pain to joints got pressured. Based on several previous studies, it known incidence osteoarthritis correlated with synovial inflammation inflammatory cytokines play an important role expansion osteoarthritis. these things, author intends conduct literature study aim knowing knee The research was conducted through PubMed Science Direct databases. results showed played negative different roles depending type such as those found inflammation. Conclusion: Cytokines have effect because they can disrupt tissue balance, induce catabolic processes, osteoclast differentiation subchondral bone resorption.